Molecular mechanisms of glucocorticoid action: what is important?
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چکیده
منابع مشابه
Molecular mechanisms of glucocorticoid action: what is important?
Biological eVects of glucocorticoids Inflammatory diseases such as asthma and rheumatoid arthritis are characterised at the molecular level by chronically increased expression of multiple cytokines, chemokines, kinins and their receptors, adhesion molecules, and inflammatory enzymes such as inducible nitric oxide synthase (iNOS) and the inducible cyclooxygenase (COX-2). At the cellular level, i...
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Glucocorticoids are the most effective therapy for the treatment of many chronic infl ammatory diseases such as asthma and infl ammatory bowel disease (Ito et al., 2006a). In contrast to the situation in asthma, chronic obstructive pulmonary disease (COPD), a common and debilitating chronic infl ammatory disease of the lung, is glucocorticoid insensitive (Barnes, 2000a, b; Culpitt et al., 2003)...
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Glucocorticoids (GC) are the most common used anti-inflammatory and immunosuppressive drugs in the treatment of rheumatic and other inflammatory diseases. Their therapeutic effects are considered to be mediated by four different mechanisms of action: the classical genomic mechanism of action caused by the cytosolic glucocorticoid receptor (cGCR); secondary non-genomic effects which are also ini...
متن کامل[Molecular mechanism of glucocorticoid action].
Glucocorticoids act on target cells via two isoforms of intracellular glucocorticoid receptors (GRs) called GRα (hormone-binding form) and GRβ which does not bind any glucocorticoids. A cycle of Hsp90 chaperone and co-chaperones maintains the functional status of GRs and their recycling. The binding of a glucocorticoid hormone to GRα leads to its activation and translocation from the cytoplasm ...
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The innate immune system and its complex interplay with the adaptive immune system are increasingly being recognized as important factors in the pathogenesis of chronic rhinosinusitis (CRS). Adaptive immune components, including resident and inflammatory cells, and their associated mediators, have been the subject of most research in CRS. For this reason, theories of CRS pathogenesis have invol...
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ژورنال
عنوان ژورنال: Thorax
سال: 2000
ISSN: 0040-6376
DOI: 10.1136/thorax.55.7.603